منابع مشابه
Physiological and Pharmacopathological Role of Dopamine Receptors and Brain Dopamine Systems
This article has no abstract
متن کاملIn reply: elevated d2 dopamine receptors in drug-naive schizophrenics.
In postmortem studies of patients with schizophrenia, D2 dopamine receptors in the basal ganglia have been observed to be more numerous than in patients with no history of neurological or psychiatric disease. Because most patients with schizophrenia are treated with neuroleptic drugs that block D2 dopamine receptors in the caudate nucleus, it has been suggested that this increase in the number ...
متن کاملPM361. The hallucinogen D-lysergic diethylamide (LSD) decreases dopamine firing activity through 5-HT1A, D2 and TAAR1 receptors
d-lysergic diethylamide (LSD) is a hallucinogenic drug that interacts with the serotonin (5-HT) system binding to 5-HT1 and 5-HT2 receptors. Little is known about its potential interactions with the dopamine (DA) neurons of the ventral tegmental area (VTA). Using in-vivo electrophysiology in male adult rats, we evaluated the effects of cumulative doses of LSD on VTA DA neuronal activity, compar...
متن کاملDopamine receptors and schizophrenia.
202 Introduction Dopamine systems have long been implicated in schizophrenia and its treatment. There is, however, little evidence for a primary abnormality of dopaminergic innervation in the disease, although subtle neuronal deficits, for which there is substantial evidence in the brain in schizophrenia, could conceivably affect dopaminergic neurotransmission in an indirect manner. However, do...
متن کاملDopamine Receptors
It was not until the late 1950’s that dopamine was recognised as a neurotransmitter in its own right when the demonstration of its non-uniform distribution in the brain suggested a specific functional role for dopamine. Interest in dopamine was intensified by the realisation that dopamine had an important role in the pathogenesis or drug treatment of certain brain History diseases e.g. Parkinso...
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ژورنال
عنوان ژورنال: Nature
سال: 1975
ISSN: 0028-0836,1476-4687
DOI: 10.1038/257070a0